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Nucleofill Strong | Promoitalia Medical Technology Natural Polynucleotide-based Bio-stimulating Gel | Long Lasting | Global Satisfaction | 1pcs*1.5ml | 2.5% Polynucleotide Gel

Nucleofill is the new line of natural polynucleotide-based bio stimulating gels, with a high viscosity, for protecting and rejuvenating the skin.
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Nucleofill is the new line of natural polynucleotide-based bio stimulating gels, with a high viscosity, for protecting and rejuvenating the skin.


The unique features of Nucleofill

The product contains high molecular weight polynucleotide chains whose biochemical peculiarities make it highly viscoelastic and capable of binding and orienting in space a considerable amount of water molecules, which are primarily retained in the hydrophilic groups level of phosphorylated sugars of the individual nucleotides. 

Originally created for the malar and sub-malar areas due to their predisposition to dermal atrophy caused by the aging phenomena, the BAP Technique is the most widespread and highly recommended protocol for treating these areas.

Moisturizing Effect

The strong moisturizing ability is mainly due to the water retention capabilities of the hydrophilic groups of the phosphorylated sugars of the single nucleotides. An “electrostatic sponge” is able to guarantee cellular well-being by conferring deep hydration to tissues.

Free radical scavenger Effect

The polymeric macromolecules are able to also play an immediate "scavenger" action against free radicals.
This effect of this polynucleotide gel is possible thanks to the chemical structure capable of blocking free radicals in the nitrogenous ring.
Moreover, the progressive degradation of polynucleotide molecules by enzymes present in the extracellular environment, free metabolites which, in turn, accentuate the protection activity against free radicals.

Biostimulating Effect

The bio-stimulating effect is given both by the presence of nucleoside structures capable of activating cell membrane receptors and by metabolites that are produced by the enzymatic attack during the degradation process. A slow and continuous effect.

Nucleofill vs. Dermal Fillers

Skinboosters use the principle of replacing lost hyaluronic acid in our skin to restore hydration and elasticity while Fillers are designed to replace lost volume or fill-up folds.
Nucleofill is not a dermal filler, nor is it a skin booster. While it is also a Hyaluronic Acid-based product, it is designed to remodel multi-layer skin tissue. It works in the epidermis, dermis, and superficial fat compartments to target and treat the source of aging and not just the aging symptoms.

Where can Nucleofill be injected?

Nucleofill is most commonly used on the cheek area and lower face, but can also be used to improve the appearance of the skin in the following areas:

  • Skin regeneration
  • Cleansing effect on the cells by increasing circulation and removing  free radicals
  • Deep moisturizing effect
  • Firming and contouring
  • Loose skin with poor circulation
  • Dehydrated skin
  • Skin submitted to oxidative stress
  • Stretch marks
  • Scars
  • For those who want to firm and contour, more definition
  • Bio-stimulation and increase in collagen type 1.

It’s recommended to have 2 treatments with 2-4 weeks in between each session, in severe cases you can have up to 4 treatments with 2-4 weeks intervals.


  • Polynucleotide gel at 2.5%
  • Glass vials of 1.5ml
  • Ph between 6.8-7.5
  • Viscosity: 48-65 pa*s
  • 2pcs 30G*13mm needles

Side Effects

Bruising may occur

Some swelling in the injection area 1-2 days

No other side effects have been reported.


  • hypersensitivity to one of the components,
  • skin infection near the site of injection,
  • patients susceptible to keloid formation,
  • pregnant or lactating women,
  • allergy or anaphylaxis,
  • bleeding disorders,
  • autoimmune disorders,
  • antibiotic therapy.



The skin will be introduced to the biostimulation process. It will start to regenerate, thicken and firm. Additional antioxidant and moisturizing effects will help to notice a visible rejuvenation of the skin, which at the same time becomes radiant, and the symptoms of oxidative stress disappear.

The skin tone will improve and fine wrinkles will vanish.

The effect will be exactly what is expected – visible but natural, without changing facial features.


Perfect for people who notice the loss of elasticity and signs of aging, the skin lacks radiance and requires deep hydration. The treatment can be performed regardless of age and skin type!


The product is completely natural and safe. Does not contain substances that could be potentially sensitizing or causing allergies. It comes in the form of a transparent gel.


Depending on the condition of the skin, the Nucleofill Medium or Nucleofill Strong can be selected.

The product is administered using the bap technique (5 points on each side of the face) to lift the skin and improve the facial contour.

People who are quite sensitive can ask for an anesthetic cream to be applied before the procedure.


As a result of the Nucleofill treatment, the skin is introduced to the biostimulation process. This starts the regenerating process, and skin becomes denser and firmer. The antioxidant and moisturizing effect make it visibly rejuvenated. Small wrinkles are reduced, and the skin becomes radiant and even in color.

If the skin is younger or doesn’t have many wrinkles or discoloration the first treatment may already bring the desired effect!

The results are visible but look natural without changing facial features.


The treatment is designed for all people who notice the loss of elasticity and signs of aging, but also those who have problems with proper skin hydration. The treatment can be used regardless of gender, age, and skin type.



Package List 1 x 1.5ml prefilled syringe needles: 2pcs 30G13mm Needles



1, Air Express (DHL/FedEx/UPS)
Delivery time:  5-7 business days
Delivery country: over 100 countries including the USA, Canada, Australia, Chile, Ecuador, Japan, EU, etc…  
Importation duty: The buyer covers importation duty depending on the destination's customs regulations. 
2, Air Economy
Delivery time:  For items below 2KG, it takes about 21~30 days;    
Delivery country: over 100 countries including the USA, Canada, Australia, Chile, Ecuador, Japan, EU, etc. 
Importation duty: covers importation duty. 
3, Free shipping* for an order over 500 US dollars after a discount or coupon/promo code
(1) Items below 35KG
Delivery time: about 14~21 days depending on the actual situation.
Delivery method:  Air Cargo shipping to the destination country, then transferred to the local courier for delivery. Usually online tracking information will be updated after 10 days.
(1) Items over 35KG
Delivery time: about 45 days depending on the actual situation.
Delivery method:  Ocean shipping to the destination country, then transferred to the local courier for delivery. Usually online tracking information will be updated after 30 days.
Delivery country: currently we only deliver to the USA, Canada, Australia, the UK, New Zealand. EU, Japan, South Korea, Singapore, China, Malaysia and Vietnam.
Importation duty: covers importation duty.
Excludes: special items such as gas or liquid.
Remote regions may cause extra for delivery to the door.
Please refresh the checkout page if you change the cart in case the free shipping option doesn't show up.

Warehouse working time: 9:00 am~ 6:pm (Monday to Friday; GMT+8). 

Due to the complex of international shipment, there are common occasions where the lead time is substantially extended due to customs and local post office handling. The case of delay is particularly high during periods of public holidays, festive seasons, and adverse weather conditions. Please understand that we do try our best to dispatch orders as soon as they are received, and we thank you for remaining patient while your order is being delivered.


We accept payment by Credit Card, T/T(Wire Transfer), Western Union, and MoneyGram. 
Please note:  We DO NOT accept Credit Card payments for product value of a single unit over 1,500 USD.
If you are not happy with the order and the product, you can ask for a refund after receiving the package. Our customer support will assist you with it.
Taxes and Duties
We do not add taxes, VAT, or any other hidden charges. You pay us what you see on your invoice, for example, Goods Subtotal + Shipping Costs (does not include duties). Please find out as much as you can about import taxes in your own country before purchasing an item. In special cases, you may need to pay import duties on certain goods. You can contact us for further assistance on any of this.  




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