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NABOTA 100U | Purified Botulinum Toxin Type A Complex | Better Botox Injections

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  • Buy 20 for $90.00 each and save 18%

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Each vial contains

  • Stabilizer: Human serum albumin 0.5mg (Korean Minimum Requirement for Biopharmaceutical Product) 
  • Isotonic agent: Sodium chloride (USP) 0.9mg

* One unit(U) of NABOTA corresponds to the calculated median intraperitoneal lethal dose (LD50) in mice.


It appears as a white to yellowish, vacuum-dried powder for injection in a colorless and transparent vial. It should become colorless transparent liquid when dissolved in the diluent (physiological saline solution).

Why Choose NABOTA?

Patented Technology

NABOTA was developed with 30 years of experience in biotechnology.

NABOTA ensures the quality of international standards via its own patented purification process(Patent registration KR 10-1339349 in 2013)


Reduced Impurity

NABOTA is a highly purified product manufactured with a patented purification process from which impurities are removed as much as possible.

Overseas Expansion

Excellence in the quality of NABOTA has led to contracts to export the finished product to about 90 countries including the United States and 28 European countries.

Proven Efficacy & Safety

NABOTA demonstrates a rapid onset of improvement effects in glabella lines.

Rapid improvement in glabella lines

Responder rate: The number of the patient or the rate of the entire patients whose evaluation score decreased over one point.

Method of evaluation: At maximal frown, independent physician grades the level of glabella lines according to 0 point (none), 1 point (mild level), 2 point (moderate level), 3 point (severe level).

Methodology: single group, open, single center, phase IV
intramuscular inject of total 20U in 5 sites (0.1mL(4U) per site) in the glabella lines
evaluate improvement rate and safety in glabella lines at 2, 3, 4, 5, 14 days after injection.

Subjects: participants with glabella lines of at least moderate severity at maximum frown (n=44)

Results: NABOTA shows improvement effects in glabella lines after two days of injection. (Improvement rate: 85.37%)

NABOTA is effective in improving glabella lines.

Improvement in glabella lines

Responder rate: percentage of subjects with a score of none(0) or mild(1).
Method of evaluation: Investigator assessed the glabella line severity at maximum frown using a four-point scale: 0=none, 1=mild, 2=moderate, 3=severe.

Satisfaction rate: percentage of subjects who scored more than six-point(satisfied or very satisfied)
Method of evaluation: satisfaction was assessed using the following seven-category scale: 1=very dissatisfied, 2=dissatisfied, 3=somewhat dissatisfied, 4=indifferent, 5=somewhat satisfied, 6=satisfied, 7=very satisfied.

Methodology: prospective, double-blinded, randomized, active-controlled, phase III study.
instramuscular injection of total 20U in 5 sites(0.1mL(4U) per site) of glabella line and evaluate 4, 8, 12, 16 weeks after injection.

Subjects: participants with glabella lines of at least moderate severity at maximum frown (N=268)


  • NABOTA demonstrates an improvement effect in glabella lines and high patient satisfaction.
  • NABOTA demonstrates to be non-inferior when compared with A product.

NABOTA did not form antibody in phase III

Antibody is not formed in glabella lines.

Methodology: active-controlled, double-blind, randomized, multicenter, phase III upon screening visit and closing visit of patients, to collect 12mL blood each, separate serum and analyze antibody formation with mouse bioassay(MBA)

Subjects: participants with glabella lines of at least moderate severity at maximum frown(n=135)

Results: Tested for 16 weeks to check if the patients have antibody after NABOTA injection, all patients did not have new antibody after 16 weeks with small doses of 20 units.

Antibody is not formed in post-stroke upper limb spasticity.

Methodology: active-controlled, double-blind, randomized, multicenter, phase III upon screening visit and closing visit of patients, to collect 12mL blood each, separate serum and analyze antibody formation with mouse bioassay(MBA)

Subjects: adult participants with post-stroke upper limb spasticity(n=197)

Results: Tested for 12 weeks to check if the patients have antibody after NABOTA injection, all patients did not have new antibody after 12 weeks with larger doses of 360 units,

Reconstitution and Dilution Technique

  1. Using an appropriate syringe, draw nonpreserved sterile saline (see dilution table below). 0.9% Sodium Chloride is the recommended diluent.
  2. Insert the needle and slowly inject the saline into the NABOTA vial in which vacuum is present.
  3. Inject slowly and avoid forming bubbles.
  4. Gently mix lyophilized NABOTA until it is completely clear and no particles are visible.
  5. Record the date and time of reconstitution. The solution should be administered within 24 hours after reconstitution.
  6. Reconstituted product should be stored in a refrigerator (2~8℃).


Stability after Dilution

Stability at freezing temperature after dilution (-15~-25℃)

Stability at room temperature after dilution (15~25℃)

Stability after repetitive freezing/thawing after dilution (-15~-25℃/2~8℃)

Cycle: regarded freezing (7days=-15~-25, 7days) and thawing(2~8℃, 48 hours) of solution as 1 cycle, repeated the cycle 4 times.

Methodology: conducted potency test using 3 batches of NABOTA 100U finished products, and measured the average value as potency. confirmed the stability of 100U NABOTA diluted in saline through animal potency test at room temperature, freezing and repetition of freezing/thawing conditions.

Results: The potency of NABOTA was proven to be effective when stored in a freezer for up to 4 months, room temperature for up to 5 weeks and repetition of freezing/thawing carried out up to 4 times after reconstitution.

Indication and Usage

Temporary improvement of forehead lines associated with corrugator and/or procerus muscle activity in adult patients between 20 to 65 years old

Upper limb spasticity after stroke in adult patients above 18 years old

Dilution Method



The unopened lyophilized vial should be stored in a freezer(blow -5℃) or refrigerator (2~8℃).

How supplied

NABOTA is supplied in a single-use vial.


The shelf-life of NABOTA is 36 months from the manufacturing date.



Voltage No
Materials No
Package Size(cm) No
Gross Weight 0.1KG



Normally express door-to-door air shipping by DHL/FEDEX is used for most of our shipments as it’s fast, safe, and convenient. You can easily track your shipment online.
Orders are processed in the order they are received. An order confirmation email containing your order details will be sent. When your order ships, you will receive a confirmation email containing the shipment tracking number.  For express door-to-door air shipping by DHL/FEDEX, delivery time is 3-7 business days
We provide shipment service to over 100 countries including the USA, Canada, Australia, Chile, Ecuador, Japan, Spain, Germany, UK, Finland, etc…  
We ship worldwide via courier (DHL/FEDEX/UPS), EMS, Airmail, Air cargo, or Ocean shipping. Ocean shipping delivery times are 20-40 business days, not including weekends and holidays. 
If you need other shipping methods such as EMS, airmail, or air cargo, please get in touch with us for assistance.
Why not provide free shipping? 
As the factory directly selling, we are offering the best price possible as we can. There is no commission fee and no hidden charges. Our pricing system is transparent and carefully calculated. For shipping costs, different countries have different shipping rates. Different package weights also result in very different shipping rates. We have a network of logistic service providers (DHL/FEDEX/UPS) which ensure the best shipping rate, fastest shipment, and reliable service. The shipping cost is automatically calculated when checking out.  
Warehouse working time: 9:00 am~ 6:pm (Monday to Friday; GMT+8). 
Note: Due to the complex of international shipment, there are common occasions where the lead time is substantially extended due to customs and local post office handling. The case of delay is particularly high during periods of public holidays, festive seasons, and adverse weather conditions. Please understand that we do try our best to dispatch orders as soon as they are received, and we thank you for remaining patient while your order is being delivered.


We accept payment by Credit Card, T/T(Wire Transfer), Western Union, and MoneyGram. After the order is placed, a confirmation email will be sent to you. Please check the email and confirm the order and delivery address. The order will be processed once you receive your confirmation. You can log in to your account and click” Orders” to check the order status. Please make sure you have sufficient information about the product and know all the terms and conditions of the purchase before making the payment. If you are not happy with the order and the product, you can ask for a refund after receiving the package. Our customer support will assist you with it.

Please note we DO NOT accept Credit Card payments for product value of a single unit over 1,500 USD. Also 

COD payment is not accepted.
For a single unit value over 1,500 USD,  please choose payment by T/T, Western Union, and Moneygram. All of these payment methods are widely used for international business. Our operators are happy to take your order per phone every business day from 9 a.m. to 6 p.m (UTC).
Please click here to learn more about payment options and how to make payments online.
Taxes and Duties
We do not add taxes, VAT, or any other hidden charges. You pay us what you see on your invoice, for example, Goods Subtotal + Shipping Costs (does not include duties). Please find out as much as you can about import taxes in your own country before purchasing an item. In special cases, you may need to pay import duties on certain goods. For assistance on any of this, you can contact us for further assistance.  
Is there any way we can avoid or reduce importation duty?
For most countries, the answer is Yes. Please contact us directly for further assistance. 




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