ELECTROPORATION (EP) is a way (method) of transmitting substances which hold certain amount of molecules (below 40,000 Dalton) through cell membrane. Electronic pulse manipulates (disturbs) phospholipids bilayer and it makes temporary pores at skin layer. Then, the drugs penetrate into internal cell through the pores. The principal of electroporation is that pore is closed when electronic pulse stop. Electroporation does not change biological structures and functions of cells and is used as a non-chemical way of transmitting DNA and various outside substances into the living cells.